Original installment
Weapon X was originally mentioned in the first appearance of Wolverine in The Incredible Hulk #180 (1974). In the 1991 story arc "Weapon X" (originally published in Marvel Comics Presents #72–84 in 1991), the project was designated Experiment X, and it was revealed that it was responsible for brainwashing Wolverine to become an assassin and binding adamantium to his skeleton. Wolverine later escapes from Weapon X, killing Dale Rice and dozens of other members.
Weapon X operated through Canada's Department K and was directed by Professor Andre Thorton, with Sublime leading Weapon X's parent organization Weapon Plus. Some of the work of Weapon X was based on the experiments detailed on the journals of Nazi scientist Nathan Essex.
The project's original test subjects were the members of Team X, a covert ops CIA team (consisting of Wolverine, Sabretooth, Maverick, Silver Fox, Mastodon, Arthur Barrington, Psi-Borg/Aldo Ferro, Wildcat/Noel Higgins, and Kestrel). Psi-Borg was involved in the creation of the victims' memory implants, in exchange for being given immortality. The test subjects were policed by an adaptive robot enforcer, called Shiva, should any of the agents go rogue. Subsequent attempts at recreating the success seen by Weapon X with Wolverine include Native, Kimura, and X-23 (a clone of Wolverine who was designed to hunt down rogue agents). The Weapon X Re-Creation Project, also known as the Facility, is headed by Martin Sutter, Dale Rice's son Zander Rice, and Sarah Kinney. Later creations of the Facility, now under the direction of Dr. Adam Harkins, include Predator X.
Second installment
At some point, Weapon X branched off from Weapon Plus' control and is solely headed up by Canada's Department K. A new generation of agents were created: Deadpool, Garrison Kane, Slayback, Sluggo, Wyre, Wild Child, and Ajax, among others. Weapon X used Logan's DNA to endow its agents with healing powers. The batch produced many additional failures, which were sent to a facility for dissection to determine the cause of their failures. These rejects are freed by Deadpool when he escapes from the facility.
Typhoid Mary is captured by an Antarctic facility continuing research for the Weapon X project, specifically the mental faculties of the mutant mind. Their experiments create Mary's "Bloody Mary" persona, who possesses increased psychokinetic powers.
Third installment
In Weapon X series number 6, director Malcolm Colcord forms the third version of the Weapon X project, designed to monitor and eliminate mutants. Colcord, once a security guard at the first Weapon X project, suffered severe facial lacerations during an escape attempt by Wolverine. Unlike the previous two installments of Weapon X, the third project was completely U.S.-based and focused not only on the creation of living weapons, but also on the ultimate goal of Colcord: the creation of death camps where mutants are either executed or forced to serve Weapon X.[1]
The agents of the third Weapon X are Brent Jackson, a former S.H.I.E.L.D. agent; Sabretooth, who is given new adamantium implants; the shapeshifter Copycat; Deadpool; and Mauvais. Later on, Deadpool goes rogue and new operatives were recruited into Weapon X, many of whom have their powers enhanced or are brainwashed into servitude. Maverick is saved from certain death and his powers are enhanced with the purpose of assassinating Wolverine. Wild Child is brainwashed and further mutated into a feral form. Unbeknownst to all except Sabretooth, Mister Sinister is disguised as Robert Windsor, the head scientist at the Neverland facility. As Windsor, Sinister rescues mutants from Neverland for his own use.
After some time, Brent Jackson takes over as director, during a mutiny by the team in conjunction with an attack by mutants from the Underground. Cable leads this group, in a mission to destroy Weapon X and expose its existence and its human rights violations. Washout and Garrison Kane are killed, while Sabretooth is washed away into the sewers after a battle with Marrow
Fourth installment
As part of the RessurXion event, a fourth installment of the Weapon X project debuted.[2] During the Weapons of Mutant Destruction storyline, Weapon X is interested in Lady Deathstrike, Warpath, Domino, Wolverine, and Sabretooth for a new experiment. It is shown that Weapon X is turning civilians into cyborgs made of adamantium sent to hunt a specific group of mutants, forcing Old Man Logan to team up with Sabretooth to stop them.[3] Logan and his allies alongside Amadeus Cho discover that Weapon X has been experimenting on humans by grafting the DNA of Wolverine and Hulk into them while also applying Adamantium to their bones. In addition, it is shown that the director of the latest incarnation of Weapon X is William Stryker.[4]
Later, Weapon X creates H-Alpha, a mutate with the abilities of Amadeus Cho and Logan.[5]
Implosion and Xeno emergence
After Krakoa is established as a mutant nation, Professor X has Weapon X and related shadow agencies disbanded. The remnants of these agencies establish Xeno, a global organization with ties to anti-mutant politicians and business leaders. Upon discovering this, Professor X tasks Domino with infiltrating Xeno to gather intel. Domino is discovered during her infiltration, and Xeno's operatives use grafts of her skin on their genetically altered soldiers to allow them to evade Krakoa's security protocols. The Xeno strike team attacks Krakoa and assassinates Xavier.[6]
Weapon X-31
Weapon X's next project appears to involve resurrecting the remains of New U Technologies' reanimations from Dead No More: The Clone Conspiracy (souls of the deceased drawn into clone bodies by Ben Reilly), beginning with Gwen Stacy, growing her reanimated severed head ('the sample') a new body and implanting adamantium blades and a healing factor into her. This project is overseen by the Great Architect, who designates Stacy as Weapon X-31 and dresses her in a purple version of Gwen Poole's uniform. After Poole is accidentally killed by X-31 while unused to her blades, Poole's ghost attempts to seek revenge on Stacy before speaking to her and, on learning about her origin, joining forces to go after the Great Architect. Spider-Man and Poole's family (partner Kate Bishop and pet/son Jeff the Land Shark) arrive and help fight the Weapon X soldiers. Spider-Man unmasks the Great Architect and X-31 goes in for the kill, but spares his life at Poole's insistence, after Poole returns to life by possessing her own corpse (Weapon X-32).[7]