EC Comics and afterward
Crandall went on to become a mainstay of EC Comics, whose line of hit horror and science fiction titles would become as influential to future generations of comics creators as they were controversial in their own time due to their often graphic nature and mature themes. Joining a group that included artists Johnny Craig, Jack Davis, Will Elder, Frank Frazetta, Graham Ingels, Jack Kamen, Bernard Krigstein and Wally Wood, Crandall made his debut there with the seven-page story "Carrion Death," written by Al Feldstein, in Shock SuspenStories #9 (June-July 1953).
He drew dozens of stories across a variety of genres for the EC anthologies Crime SuspenStories, Shock SuspenStories, Tales from the Crypt, Two-Fisted Tales, The Vault of Horror, The Haunt of Fear, Extra!, Impact, Piracy, and Weird Fantasy and its sequel series, Weird Science-Fantasy.
Following the demise of EC in the wake of the 1954 U.S. Senate hearings on juvenile delinquency and a wave of anti-comics sentiment,[14] Reed freelanced for Atlas Comics, the 1950s iteration of Marvel Comics, as well as for the Gilberton Company's Classics Illustrated. Crandall's work for Classics Illustrated consisted of joint projects with EC veteran George Evans on four titles: No. 18, The Hunchback of Notre Dame (Fall 1960); No. 23, Oliver Twist (Fall 1961); No. 68, Julius Caesar (1962); No. 168, In Freedom's Cause (completed 1962; published UK 1963; published US 1969).[15]
In 1960, he went under contract with the publisher of Treasure Chest, a comic book distributed exclusively through parochial schools. Crandall illustrated many covers and countless stories for Treasure Chest through 1972. In 1964, he illustrated books by Edgar Rice Burroughs for Canaveral Press. The following year, he began contributing to Warren Publishing's black-and-white war-comics magazine Blazing Combat, and soon went on to contribute to the company's line of black-and-white horror publications, including Creepy and Eerie. In the mid-to-late 1960s, he illustrated superhero-espionage stories for Tower Comics,[16] and space opera science fiction in King Features Syndicate's King Comics comic-book version of the syndicate's long-running hero Flash Gordon.[17]
In June 1970, Crandall and Buster Crabbe were guests at the Multicon-70 convention in Oklahoma City.[18]