Mercedes-Benz has sold a number of automobiles with the "280" model name:
- 1959–1968 W111
- 1967–1971 280SE Coupe & Cabrio
- 1969–1971 280SE 3.5 Coupe & Cabrio
- 1968–1971 W113
- 1968–1971 280SL
- 1965–1973 W108
- 1968–1972 280SEL
- 1968–1972 280SE
- 1969–1971 280S
- 1971–1973 280SEL 3.5 (& 4.5 - North America only)
- 1971–1973 280SE 3.5 (& 4.5 - North America only)
- 1972–1976 W114
- 1972–1976 280
- 1973–1976 280C + 280CE
- 1975–1980 W116
- 1975–1976 280S
- 1977–1980 280SE + SEL
- 1977–1981 W123
- 1977–1981 280E
- 1975/12–1986/01 W123
- 1975/12–1981/07 280
- 1975/12–1985/12 280E
- 1977/04–1980/03 280C
- 1977/04–1985/08 280CE
- 1978/05–1986/01 280TE
- 1994 W202
- 1994 C280