Fernandes is a fan of English club West Ham United and was involved in talks regarding a potential takeover of the club in May 2011, at which stage it looked as if he was going to acquire a 51% stake in the club. Former West Ham chairman Andrew Bernhardt even flew to Kuala Lumpur to try and finalise the deal, but the two parties failed to agree on the price.[34] It was just one month later when Fernandes made another offer to buy 51 per cent of the club, although co-owners David Sullivan and David Gold rejected his bid. Sullivan told the Evening Standard: "He wanted 51% of the club for two bob." Sullivan's comments started a war of words on Twitter. "It was a good offer with good money and brought in good people," said Fernandes. "Gold and Sullivan can say whatever they want. I have been a lifelong fan and would have brought good money, good ideas, new people and a new belief. As for PR stunts. Wow. They are always in the press making huge claims. Were we not supposed to be in Europe. Now we have been relegated. Two sacked managers. All good players will be sold. No new training ground which is the most important ingredient I feel. Look at how many injuries we have. And more investment into the academy."[35]
On 18 August 2011, just three months after Queens Park Rangers' promotion back to the Premier League following a 15-year absence, Fernandes was unveiled as their majority shareholder, having bought Bernie Ecclestone's 66% stake. He was also named as chairman of QPR Holdings Ltd.[36]
While Neil Warnock remained as the club's manager for their return to the top-flight, a run of eight Premier League games without a win eventually led to his sacking.[37] Mark Hughes was quickly named as his replacement, signing a two-and-a-half-year deal in the process.[38] Despite their new manager, QPR's poor run of form continued, which left them fighting for Premier League survival on the final day of the 2011–2012 season. Relegation rivals Bolton Wanderers needed a win to have any chance of survival, but could only muster a draw with Stoke City,[39] meaning QPR were safe, despite losing 3–2 to Manchester City after Sergio Agüero's injury-time winner – a goal which stole the Premier League title from arch-rivals Manchester United on goal difference.[40]
Mark Hughes led the club into the 2012–2013 season, but after just four points from 12 games and without a single win – one of the worst starts in Premier League history – Fernandes dismissed Hughes.[41][42] Fernandes hired former Tottenham Hotspur manager Harry Redknapp on 24 November 2012,[43][44] but he was also unable to solve QPR's problems. Following a goalless draw with relegation rivals Reading on 28 April 2013, both teams were relegated to the Championship.[45]
Speaking to the media just one week after Rangers' relegation back to the Championship, Fernandes said he had been exploited since he took over at Loftus Road. After investing an estimated £50 million into the club, he said: "I don't think I will be exploited any more. I think I allowed myself to be exploited but that's my choice. Agents are trying to get the best contracts and there are no two ways about it, I had to pay premiums. I've seen all of the parts that make football quite - maybe immoral is a strong word - but they would sell their grandmother to do something. It's all part of the football ecosystem."[46]
In 2013 Fernandes said in an interview that he would leave the club if he was unable to "fix" their problems.[47] In a 2017 interview, after a year in the Premier league in 2014-15 and three years relegated to the Championship league from 2015 to 2018, Fernandes admitted having made several mistakes, but also noted that much had been achieved. He restored the former QPR badge and colours and engaged more with the community near Loftus Road.[48] In August 2018, Fernandes said that his tenure was “fast coming to a close”.[49] He planned to step down and hand over the position of co-chairman to vice chairman Amit Bhatia,[49] a change finalised on 15 August 2018.[50]
On 10 July 2023, it was announced that Fernandes no longer held any shares in QPR's holding company, QPR Holdings Limited, and would no longer have involvement in the club.[51]