Paritaprevir (previously known as ABT-450) is an acylsulfonamide[1] inhibitor of the NS3-4A serine protease[2] manufactured by Abbott Laboratories[3] that shows promising results as a treatment of hepatitis C. When given in combination with ritonavir and ribavirin for 12 weeks, the rate of sustained virologic response at 24 weeks after treatment has been estimated to be 95% for those with hepatitis C virus genotype 1.[4] Resistance to treatment with paritaprevir is uncommon, because it targets the binding site, but has been seen to arise due to mutations at positions 155 and 168 in NS3.[5]
Paritaprevir was a component of Viekira Pak and Technivie.[6] In May 2018, the FDA announced that Technivie and Viekira were to be discontinued. The discontinuation was voluntary and not related to the safety, quality, or efficacy of the medicine. It was estimated that both medications would be available until January 1, 2019.[7]
References
- Hepatitis C: antiviral drug discovery and development Caister academic press, 2011, retrieved 28 April 2014^
- Hepatitis C Oxford University Press, 2013, retrieved 28 April 2014^
- Abbott Announces Phase 3 Hepatitis C Program Details Abbott company website, Abbott Laboratories, retrieved 28 April 2014^
- Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1 The New England Journal of Medicine, January 2014^
- Hepatology 2013 a clinical textbook Flying Publisher, 2013, retrieved 28 April 2014^
- TECHNIVIE™ (ombitasvir, paritaprevir and ritonavir) Tablets, for Oral Use. Full Prescribing Information AbbVie Inc., North Chicago, IL 60064, retrieved 28 July 2015^
- Current and Resolved Drug Shortages and Discontinuations Reported to FDA^