Plot
Two "Handymen" named Worick Arcangelo and Nicolas Brown take on jobs for both the mob and the police force that no one else can handle. After a job of crushing a gang, Worick decided to spare and help the amnesiac sole survivor Alex under their wing for the time being.
One day, Nicolas and Worick are brought in by the police for questioning on the mass murders that have taken place in the sixth district. All of the bodies appear to exclusively be Twilights. However, they leave quickly when Daniel Monroe calls for their assistance. Monroe is being attacked by a young Twilight named Doug, a member of the Pauklee mercenary guild. There Nicolas battles Doug to a standstill, but their fight is interrupted by the guild's head, Gina and her high-ranked assistant, Ginger. Nicolas recovers along with Doug at Dr. Theo's clinic. After recuperating, Doug divulges that his mission was given to him by the Corsica family, who are infamous anti-Twilight advocates. In addition, Daniel Monroe's right-hand man, Ivan, is revealed to be a mole for the Corsica family.
The anti-Twilights sentiment in Ergastulum steadily increases as the murder rate of Twilights continue, leading the Handymen to take a job gathering stray Twilights to be brought under the Christiano Family's protection. Hiding them within the family's club, Bastard. While Worick and Nic are out, Alex stays inside the club and is encouraged to sing for the patrons. Eventually, the club is attacked by the Twilight Hunters. Loretta's bodyguards, Galahad and Marco momentarily hold them off until Nicolas arrives and engages the Hunters in a brutal fight. Eventually they subdue Nic, preparing to kill him before his reinforcements arrive in the form of Worick, Doug, and most importantly Ginger who the two quickly realize they can't defeat. Forcing them to hastily retreat into the night.
The Paulklee Guild is attacked by two hunters, wanting to test their defenses. The figures reveal themselves as members of the Third Destroyers and agents of Uranus Corsica. In the assault, Doug is killed. Upon learning that one of the hunters is Delico's long-lost sister, Erica, him and Yang resolves to go look for her. They ask around if anyone has seen Erica, but with no luck. As they search District 7, a young Twilight named Heather attacks them, mistaking Delico for Erica. Delico and Yang manage to convince Heather to guide them to Erica's known location. After the attack on Bastard, Nic is assigned to protect Loretta and Worick goes to help reinforce the Monroe mansion. Only to find that Monroe himself is nowhere to be found. When speaking to Miles, the estate is attacked by Striker, a member of the Destroyers looking for Daniel. Striker swiftly decimates the estate's security but is eventually driven off when Worick injects him with a downer. In the conflict, Worick is stabbed and thrown out of a window.
On this same day, Connie goes to her grandmother's shop and encounters another Destroyer, Berreta. Believing she's a customer, Connie offers her some cigarettes, but Beretta proceeds to kidnap her. Being tied up and gagged, Beretta then presents Connie as a gift to Striker, who is very pleased. While Worick is recovering at Dr. Theo's clinic, Nicolas speaks to the doctor about an experimental version of Cerebret. Bestowing the user, a stable amplification of their overall strength. Injecting Nic before he sets off to search for the two Hunters. As the two parties search for Erica, Nic comes across Yang and Delico in an alleyway. He further explains that he's here to interrogate Mikhail. Also making it clear that Delico will have three chances to kill or capture Erica before he takes over and does it himself. Delico approaches their hideout in disguise to lure Mikhail out. As Nicolas fights Mikhail, Erica appears before Delico. Who she seems not to recognize, stealing his tags as he pleads for her to acknowledge him. Yang and Delico attempt to subdue Erica before Nicolas is drawn into the fight as well. Delico and Nicolas manage to immobilize Mikhail, and then Monroe and Ivan appear. Monroe reveals that he was behind the attack on the orphanage as well as Erica's kidnapping and Ivan routinely sexually assaults her revealing himself as her "handler". During this, Nic is starting to come down on the Celebret and feeling sickly. Enraged, Yang lunges forward and aiming his gun at Monroe. Delico reflexively shoots Yang in Monroe's defense, but soon realizes his mistake. Nic then attacks Daniel, who incapacitates him by shooting him in the leg. Monroe, Ivan and Erica depart, leaving the injured Mikhail behind. Not before long, Heather arrives with help from Worick, Marco and Theo.
At the clinic, Nicolas start to have a seizure as a side-effect to the experimental Cerebret and Yang is in critical condition. Theo is ready to consider his tests on Nic a failure and began to administer a downer, but Nic knocks it out of his hand, telling him to give Yang more attention. While at the Destroyers’ warehouse, Constance escapes from her restraints and stabs Sig in the thigh with a shard of glass. In retaliation, Striker tears her left arm off and sends it to Marco. Leading Marco to venture out on his own to retrieve her. On the way, Marco is ambushed by Colt, only to be saved by Galahad and the Guild. Finally reaching the warehouse, Marco battles Striker and Beretta. After fleeing with Constance, Striker catches up with them, leading the couple to use a suicide bomb as a last resort. Leaving Striker critically injured.
Shortly after the appearance of the Hunters and Destroyers in Ergastulum, Worick murders Miles and presents the severed head to the Corsica family, leaving behind some money and a note for Alex, telling her to leave the city while she still can. While Nicolas is recovering at the Theo's clinic, four members of the Guild attempt to apprehend him, Theo and Alex. Nic attempts to fight them off but is unsuccessful. The Guild brings them into custody for questioning. Worick begins working for Corsica under the name "Storage". Utilizing his photographic memory as his strongest asset. While meeting with Uranos, its revealed that Corsica placed the Hunters under his control. So, they may carry out the annihilation of all Twilights within the city.