Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, and sold under the trade name Rifater, is a medication used to treat tuberculosis. It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide. It is used either by itself or along with other antituberculosis medication. It is taken by mouth.[1]
Side effects are those of the underlying medications.[1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness.[2] Severe side effects include liver problems. Use in those under the age of 15 may not be appropriate. It is unclear if use in pregnancy is safe for the baby.[3]
Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994.[3] It is on the World Health Organization's List of Essential Medicines.[4]
Medical uses
The hope of a fixed-dose combination pill is to increase the likelihood that people will take all of three medications.[5] Also, if people forget to take one or two of their drugs, they might not then develop resistance to the remaining drugs.
Society and culture
It is manufactured by Aventis.
See also
- Tuberculosis treatment
- Rifampicin + isoniazid + ethambutol
References
- WHO Model Formulary 2008 World Health Organization, 2009^
- Rifater Side Effects in Detail - Drugs.com www.drugs.com, retrieved 18 December 2016^
- Rifater - FDA prescribing information, side effects and uses www.drugs.com, October 2016, retrieved 18 December 2016^
- World Health Organization model list of essential medicines: 21st list 2019 World Health Organization, 2019^
- Clinical Pharmacology Elsevier Health Sciences, 2012-07-30^