Mazdutide

drug name	Mazdutide
synonyms	IBI362; LY3305677
routes of administration	Injection
legal status	Rx in China, Investigational in general
cas number	2259884-03-0
pubchem	167312357
unii	MB76Z4IBZ5
drugbank	DB19099
chemspiderid	129341158
stdinchi	1S/C210H322N46O67/c1-117(2)93-145(191(300)233-139(70-76-170(276)277)181(290)224-107-164(269)222-109-168(273)256-86-46-57-159(256)204(313)249-157(112-259)203(312)247-155(110-257)183(292)223-106-161(216)266)237-192(301)146(94-118(3)4)239-196(305)152(100-128-104-221-134-52-37-36-51-132(128)134)243-190(299)143(73-79-173(282)283)236-205(314)176(120(7)8)253-199(308)150(96-124-47-30-28-31-48-124)241-189(298)142(72-78-172(280)281)234-185(294)136(56-41-45-83-218-166(271)114-322-91-90-321-88-85-220-167(272)115-323-92-89-320-87-84-219-162(267)75-69-144(208(317)318)228-163(268)58-34-26-24-22-20-18-16-14-15-17-19-21-23-25-27-35-59-169(274)275)229-179(288)121(9)227-184(293)135(53-38-42-80-211)230-186(295)137(54-39-43-81-212)231-188(297)141(71-77-171(278)279)235-197(306)153(102-174(284)285)244-193(302)147(95-119(5)6)238-194(303)148(98-126-60-64-130(263)65-61-126)240-187(296)138(55-40-44-82-213)232-201(310)156(111-258)248-195(304)149(99-127-62-66-131(264)67-63-127)242-198(307)154(103-175(286)287)245-202(311)158(113-260)250-207(316)178(123(11)262)254-200(309)151(97-125-49-32-29-33-50-125)246-206(315)177(122(10)261)252-165(270)108-225-182(291)140(68-74-160(215)265)251-209(319)210(12,13)255-180(289)133(214)101-129-105-217-116-226-129/h28-33,36-37,47-52,60-67,104-105,116-123,133,135-159,176-178,221,257-264H,14-27,34-35,38-46,53-59,68-103,106-115,211-214H2,1-13H3,(H2,215,265)(H2,216,266)(H,217,226)(H,218,271)(H,219,267)(H,220,272)(H,222,269)(H,223,292)(H,224,290)(H,225,291)(H,227,293)(H,228,268)(H,229,288)(H,230,295)(H,231,297)(H,232,310)(H,233,300)(H,234,294)(H,235,306)(H,236,314)(H,237,301)(H,238,303)(H,239,305)(H,240,296)(H,241,298)(H,242,307)(H,243,299)(H,244,302)(H,245,311)(H,246,315)(H,247,312)(H,248,304)(H,249,313)(H,250,316)(H,251,319)(H,252,270)(H,253,308)(H,254,309)(H,255,289)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,317,318)/t121-,122+,123+,133-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,176-,177-,178-/m0/s1
stdinchikey	NCZIWZAVWHEUKM-SQZAUUIPSA-N
smiles	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(N)=O
jmol	none
iupac name	20-[[(1S)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-2-methylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-20-oxoicosanoic acid \| C=210\|H=322\|N=46\|O=67\| chemical_formula = \| molecular_weight = \|undefined

Mazdutide (also known as IBI362 or LY3305677) is a dual agonist of the GLP-1 receptor and glucagon receptor. It is an analog of oxyntomodulin (OXM).[1][2][3] The drug is developed by Eli Lilly and Innovent Biologics. and is currently in multiple Phase III studies.[4][5] In May 2025, a result of Phase III study has shown that once-weekly mazdutide led to clinically relevant reductions in body weight in Chinese adults with overweight or obesity.[6]

In June 2025, Mazdutide injection is approved for marketing in China.[7]

References

Hongwei Jiang, Shuguang Pang, Yawei Zhang, Ting Yu, Meng Liu, Huan Deng, Li Li, Liqi Feng. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes Nature Communications, 24 June 2022^
Linong Ji, Leili Gao, Hongwei Jiang, Jing Yang, Lei Yu, Jie Wen, Chenghang Cai, Huan Deng. Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial eClinicalMedicine, December 2022^
Linong Ji, Hongwei Jiang, Pei An, Huan Deng, Meng Liu, Li Li, Liqi Feng, Baili Song. IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study eClinicalMedicine, September 2021^
Phalguni Deswal. EASD 2024: Innovent shows off mazdutide's efficacy in diabetes and obesity Clinical Trials Arena, 2024-09-12, retrieved 2024-11-10^
Next-gen Lilly obesity drug slashes weight in Innovent study—but is it enough to rival Mounjaro? 11 May 2023, retrieved 4 November 2023^
Linong Ji, Hongwei Jiang, Yan Bi, Hua Li, Junhang Tian, Dexue Liu, Yuzhu Zhao, Wei Qiu, Chongbing Huang, Lei Chen, Shao Zhong, Jie Han, Yawei Zhang, Qiufang Lian, Ping Yang, Lingchun Lv, Jieyu Gu, Zihan Liu, Huan Deng, Yanqi Wang, Li Li, Lijuan Pei, Lei Qian. Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight New England Journal of Medicine, 24 May 2025^
国家药监局批准玛仕度肽注射液上市 nmpa.gov.cn, 2025-06-27, retrieved 2025-07-05^