MGI or MGI Tech is a Chinese biotechnology company,[3] which provides a line of products and technologies that serves the genetic sequencing, genotyping and gene expression, and proteomics markets. Its headquarters are located in Shenzhen, Guangdong, China.
History
In 2016, MGI was founded as a subsidiary of BGI Group.[4][5] It manufactures high-throughput genetic sequencing systems and other products for use in the life sciences and health care sectors.[6][7] As of July 2022, the company's operation is divided into two primary business segments: genetic sequencers and laboratory automation systems.[8][9]
MGI was a subsidiary of BGI Group before, it was spun out and listed on the Shanghai stock exchange in 2022.[10]
In May 2020, MGI raised $1 billion in series B funding from IDG Capital and CPE China Fund.[11][12] In December 2020, the company submitted its IPO application to Shanghai Stock Exchange STAR Market.[13][14] In September 2021, the company has won the approval for its IPO on Shanghai Stock Exchange STAR Market's high-tech board.[15]
In 2024, MGI lost more than a third of its market capitalization after the US Congress introduced legislation to prohibit American health data being sent to China.[16]
In 2024, MGI opens Customer Experience Center in Brazil. [17]
In 2025, Swiss biotech incubator firm Swiss Rockets has entered into an exclusive licensing agreement with MGI Tech and its US subsidiary Complete Genomics granting the company the rights to develop and commercialize next-generation sequencers based on the MGI Tech/Complete Genomics' CoolMPS technology in most parts of the world. [18]
Subsidiaries
Complete Genomics
In March 2013, Complete Genomics was acquired by BGI Group.[19] After the acquisition, Complete Genomics moved to San Jose, and in June 2018 became part of MGI.[20][21] The acquisition was one of the outcomes of $1.5 billion 'collaborative funds' i.e., '10 years loan' which was initially provided by China Development Bank to acquire all 128 of Illumina, Inc.'s newest and fastest next-generation sequencers including HiSeq 2000.[22]
Research and development
The company is known for manufacturing DNA sequencers based on low-cost DNA nanoball sequencing technologies which was refined further after the acquisition of Complete Genomics.[23][24] The refinement included combinatorial probe anchor synthesis technologies which involves loading DNA nanoballs (DNBs) onto a patterned array chip using a fluidic system. Subsequently, a sequencing primer is added to the adaptor region of the DNBs in order to hybridize them.[25]
In 2023, MGI dubbed DNBSEQ-T20 which can read up to 50,000 human genomes a year. And the cost of reading each genome will be as low as $100. [26][27]
In 2025, MGI Tech unveils DNBSEQ-T1+. The DNBSEQ-T1+ is a next-generation mid-throughput sequencer that completes a paired end 150 sequencing workflow in just 24 hours with Q40 accuracy.[28]
In 2025, MGI Tech touts world’s fastest gene sequencer: 10 minutes to read a genome. The company said at a launch event that the DNBSEQ-T7+ can sequence 144 human genomes a day, or one every 10 minutes. [29]
Criticism
On October 31, 2019, the Chairman of the Senate Finance Committee, Chuck Grassley, and Senator Marco Rubio wrote a joint letter to Alex Azar, the Secretary of the Department of Health and Human Services and Seema Verma, the Administrator of the Centers for Medicare & Medicaid Services (CMS) raised their concerns against MGI, regarding the circumstances under which the CMS may finance it to process American citizens' genomic or exome data.[30]
MGI asserted that it is "a supplier of instruments and consumables for customers to use in their own labs" and does not provide any genomic sequencing services. "MGI does not own, control, handle, or even access samples or genetic data, only MGI's customers do. There is no risk that MGI will have access to any health records or genetic data from customers," the company stated.[31]
Litigation
Patents infringement lawsuit
In November 2021, a federal jury in California concluded that MGI America (in its capacity as an affiliate of BGI Group) had infringed Illumina, Inc.'s patents. Accordingly, they awarded Illumina damages of $8 million.[32]
In March 2022, Illumina persuaded a U.S. District Judge to prolong the restriction on MGI America selling its CoolMPS sequencers in the United States for six months until August 2022, when Illumina's patent expires.[33]
"Two-channel" DNA sequencing lawsuit
Complete Genomics, a research subsidiary of MGI, filed a lawsuit in May 2019, alleging that Illumina's "two-channel" DNA sequencing chemistry violates two patents for the technology that deduces the identification of each nucleotide from two signals. The NovaSeq 6000, the NextSeq 500/550/550x, and 1000/2000 Series, as well as the MiniSeq, were all the focus of the lawsuit against Illumina. Additionally, it targeted Illumina's cluster generation & sequencing, and library preparation kits, all of which are interoperable with one or more platforms.[34]
In May 2022, a jury in Delaware concluded that Illumina's "two-channel" sequencing chemistry infringes on two patents owned by MGI Tech through its subsidiary Complete Genomics. As a result of this finding, the jury awarded $333.8 million in damages to the company. The jury also dismissed Illumina's assertions that the patents were invalid. The verdict also invalidated three of Illumina's patents that the firm had asserted in a countersuit claiming MGI Tech had infringed on Illumina's patents.[35]
External links
References
- Wall Street Journal Stock Quote: MGI Tech Co Ltd retrieved 2024-04-16^
- Bloomberg company profile: MGI Tech Co Ltd Bloomberg News, retrieved 2024-04-16^
- Vera Belova, Anna Pavlova, Robert Afasizhev, Viktoriya Moskalenko, Margarita Korzhanova, Andrey Krivoy, Valery Cheranev, Boris Nikashin. System analysis of the sequencing quality of human whole exome samples on BGI NGS platform Scientific Reports, 2022-01-12^
- Elizabeth Pennisi. A $100 genome? New DNA sequencers could be a 'game changer' for biology, medicine Science, June 15, 2022, retrieved July 14, 2022^
- Antonio Regalado. China's BGI says it can sequence a genome for just $100 MIT Technology Review, 2020-02-26, retrieved 2022-07-14^
- Richard Pilch, Jill Luster, Miles Pomper, Robert Shaw. Scientific Risk Assessment of Genetic Weapon Systems Middlebury Institute of International Studies at Monterey, 2021, retrieved 2024-04-16^
- Dun Yuting. Chinese DNA sequencing company raises a record $1 billion Nikkei Asia, 2020-06-26, retrieved 2022-07-14^
- 华大智造(X20636):基因测序 星辰大海之华大智造__新浪财经_新浪网 stock.finance.sina.com.cn, retrieved 2022-07-14^
- ICG-16 www.seqchina.cn, retrieved 2022-07-14^
- Jamie Smyth, Demetri Sevastopulo. Chinese genetics company targets US despite political tensions Financial Times, 18 April 2023, retrieved 2023-04-18^
- Peng Yanfeng, Denise Jia. Coronavirus Testing Equipment Maker MGI Tech Gets $1 Billion Funding - Caixin Global Caixin Global, retrieved 2022-07-14^
- Silvia Micalo. Healthtech Innovation: How Entrepreneurs Can Define and Build the Value of Their New Products CRC Press, 2022-10-03, retrieved 2022-09-06^
- Huanjia Zhang. MGI Tech Planning to go Public in $366M Chinese IPO GenomeWeb, 2022-08-29, retrieved 2022-09-03^
- Kenneth Law, Tony Lin. 2021 China Life Sciences and Healthcare M&A Whitepaper Deloitte, September 2021, retrieved 2022-09-03^
- BGI's Gene Sequencer Spin-Off Approved for Shanghai IPO Caixin, retrieved 2024-04-16^
- America hits Chinese biotech—and its own drugmakers The Economist, April 15, 2024, retrieved 2024-04-16^
- MGI Tech abre centro de experiência do cliente no Brasil Medicina S/A, April 22, 2024, retrieved 2024-04-22^
- Swiss Rockets Exclusively Licenses Sequencing Chemistry From MGI Tech, Complete Genomics GenomeWeb, Oct 28, 2025, retrieved 2025-10-28^
- Complete Genomics, BGI Agree to $117.6M Merger GenomeWeb, 2012-09-17, retrieved 2022-07-14^
- Matthew Campbell, Dong Lyu. China's Genetics Giant Wants to Tailor Medicine to Your DNA Bloomberg Asia Edition, 2019-11-13, retrieved 2022-09-03^
- Julianna LeMieux, PhD. All Aboard the Genome Express GEN - Genetic Engineering and Biotechnology News, 2019-01-11, retrieved 2022-07-14^
- Kai Wang, Xiaobai Shen, Robin Williams. Sequencing BGI: the evolution of expertise and research organisation in the world's leading gene sequencing facility New Genetics and Society, 2021-07-03^
- Sten Anslan, Vladimir Mikryukov, Kęstutis Armolaitis, Jelena Ankuda, Dagnija Lazdina, Kristaps Makovskis, Lars Vesterdal, Inger Kappel Schmidt. Highly comparable metabarcoding results from MGI-Tech and Illumina sequencing platforms PeerJ, 2021-09-30^
- Bernd Kaspers, Karel A. Schat, Thomas Göbel, Lonneke Vervelde. Avian Immunology Academic Press, 2021-12-05, retrieved 2022-09-06^
- Zhuokun Li, Xiaojue Wang, Dongyang Xu, Dengwei Zhang, Dan Wang, Xuechen Dai, Qi Wang, Zhou Li. DNB-based on-chip motif finding: A high-throughput method to profile different types of protein-DNA interactions Science Advances, 2020-07-31^
- Chinese DNA giant’s U.S. affiliate looks to rival Illumina, touting $100 genome and high-power sequencers StatNews, 2023-02-07^
- MGI Breaks the $100 genome barrier, barely San Diego Omics, 2023-02-07^
- MGI Tech unveils high-speed sequencing solutions at AGBT 2025 Korean Biomedical Review, 2025-02-28^
- China’s MGI Tech touts world’s fastest gene sequencer: 10 minutes to read a genome South China Morning Post, 2025-09-09^
- Grassley, Rubio Seek Answers on HHS Funded Genetic Testing Connected to China, Russia www.finance.senate.gov, retrieved 2022-09-12^
- Zhang Huanjia. MGI Tech Heads Full Steam Into US Market Despite Data Security Accusations, Image Problems GenomeWeb, GenomeWeb, retrieved 19 December 2022^
- Hannah Albarazi. Jury Says BGI Owes Illumina $8M For Infringing DNA Patents - Law360 Law360, retrieved 2022-07-14^
- Blake Brittain. Illumina wins extended U.S. ban on BGI gene-sequencer sales Reuters, 2022-03-29, retrieved 2022-07-14^
- Christopher Yasiejko. Illumina Owes BGI $333.8 Million Over Gene-Sequencer Patents (2) Bloomberg Law, 2022-05-09, retrieved 2022-07-14^
- Blake Brittain. Illumina ordered to pay BGI subsidiary $333 million in DNA-sequencing patent case Reuters, 2022-05-07, retrieved 2022-07-14^