Lisinopril/hydrochlorothiazide

Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension).[2] It contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic.[2] Typically, it becomes an option once a person is doing well on the individual components. It is taken by mouth.

Common side effects include dizziness, headache, cough, and feeling tired.[2] Severe side effects may include angioedema and low blood pressure.[2] Use during pregnancy may harm the baby.[2]

The combination was approved for medical use in the United States in 1989.[3] It is on the World Health Organization's List of Essential Medicines.[4] It is available as a generic medication.[5] In 2023, the combination was the 58th most commonly prescribed medication in the United States, with more than 10million prescriptions.[6][7]

Medical uses

Lisinopril/hydrochlorothiazide is indicated for the treatment of hypertension, to lower blood pressure.[2]

Adverse effects

The US Food and Drug Administration prescribing information for the combination contains a boxed warning about harm to the baby.[2]