Laboratoires Pierre Fabre

Laboratoires Pierre Fabre is a French multinational pharmaceutical and cosmetics company headquartered in the city of Castres, Midi-Pyrénées, France.[2]

History

Founded in 1962 by Pierre Fabre (1926-2013),[2] the company is present in over 130 countries.

In 1984, Pierre Fabre Dermatologie (PFD) was founded. In 1986, Pierre Fabre Japan was established as a joint venture with Shiseido. In 1989, vinorelbine received its marketing authorisation.[3] Laboratoires Avène were also created. In 1990, the Avène thermal spa re-opened.[4] The Pierre Fabre Immunology Centre in Saint-Julien-en-Genevois was inaugurated.

Olivier Bohuon was Chief Executive from September 2010 to April 2011.[5]

In December 2014, the Group announced to trade unions the elimination of 551 positions in France (including nearly 200 in the Midi-Pyrénées region) and in Barcelona, during a central works council meeting. The Research & Development and Medical Promotion divisions were affected. A strategic plan entitled Trajectoires 2018 was launched. Although promises of internal redeployment were made for employees in Midi-Pyrénées, unions expressed concerns about potential layoffs.[6]

In March 2025, Marie-Andrée Gamache was appointed head of the Pierre Fabre Medical Care division.[7] In the autumn of the same year, the Pierre Fabre Group inaugurated its new headquarters, named "Campus Chartreuse", in Castres.[8][9]

Business

The company is focused on research, development, manufacturing and marketing of cosmetics, prescription medicines and family health products.

The company had a consolidated turnover of 1.978 billion euros in 2012 (including 54% international).[2]

Laboratories Pierre Fabre had approximately 10,000 employees in 2012, 33% of whom are internationally based, while the remaining 6,700 employees were based in France.[2]

Products

Pierre Fabre is best known for its vinorelbine (Navelbine),[10][11] an anticancer drug[12] of the vinca alkaloid class.[13][14][15]

They also developed vinflunine,[16] a fluorinated vinca alkaloid derivative[17][18] available in Australia for "advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum containing regimen."[19]

Patents

  • Pierre Fabre holds a patent for the combination of ciclopirox olamine and piroctone olamine.[20] These two active substances are highly effective when used together, creating a powerful treatment for dandruff and seborrheic dermatitis.[21]

The Pierre Fabre Foundation

The Pierre Fabre Foundation was recognized as a public utility in 1999,[22] and its mission is to enable communities from less advanced and emerging countries, as well as those plunged into severe crisis by political or economic upheaval and/or natural disaster, to access the quality and levels of everyday health care and the widely-used drugs defined by the WHO and other organisations as essential to human health.[23]

References

  1. Company Overview of Pierre Fabre S.A. retrieved December 9, 2014^
  2. Pierre Fabre, founder of pharmaceutical giant, dies Agence France Presse, France 24, 2013-07-20, retrieved 2013-08-17^
  3. Pierre Fabre, de la Navelbine aux anticorps monoclonaux 30 April 2014, retrieved 2017-11-17^
  4. Pierre Fabre investit 4,7 millions d'euros à Avène-les-Bains 25 May 2005, retrieved 2017-11-17^
  5. Olivier BOHUON appointed Chief Executive Officer of Pierre Fabre SA FierceBiotech, retrieved 2020-01-29^
  6. Plan social confirmé chez Pierre Fabre France 3 Occitanie, 2014-09-12, retrieved 2025-04-22^
  7. Marie-Andrée Gamache rejoint les Laboratoires Pierre Fabre en tant que directrice générale Pierre Fabre Medical Care ladepeche.fr, retrieved 2025-04-21^
  8. EN IMAGES. Pierre Fabre dévoile son nouveau vaisseau amiral lejournaldici.com, 2025-10-08, retrieved 2025-10-10^
  9. Castres. "Nous ramenons le siège de Pierre Fabre à la maison" lejournaldici.com, 2025-02-27, retrieved 2025-10-10^
  10. Quoc Anh Ngo, Fanny Roussi, Anthony Cormier, Sylviane Thoret, Marcel Knossow, Daniel Guénard, Françoise Guéritte. Synthesis and biological evaluation of Vinca alkaloids and phomopsin hybrids Journal of Medicinal Chemistry, 2009^
  11. Péter Keglevich, Laszlo Hazai, György Kalaus, Csaba Szántay. Modifications on the basic skeletons of vinblastine and vincristine Molecules, 2012^
  12. Bryan A. Faller, Trailokya N. Pandi. Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer Clinical Medicine Insights: Oncology, 2011^
  13. Robert van der Heijden, Denise I. Jacobs, Wim Snoeijer, Didier Hallard, Robert Verpoorte. The Catharanthus alkaloids: Pharmacognosy and biotechnology Current Medicinal Chemistry, 2004^
  14. Enrique Raviña. The evolution of drug discovery: From traditional medicines to modern drugs John Wiley & Sons, 2011^
  15. Raymond Cooper, Jeffrey John Deakin. Botanical Miracles: Chemistry of Plants That Changed the World CRC Press, 2016^
  16. Bristol-Myers Squibb and Pierre Fabre Provide Update On Vinflunine Development Status November 23, 2007, retrieved June 27, 2008^
  17. Jacques Fahy, Alain Duflos, Jean-Paul Ribet, Jean-Claude Jacquesy, Christian Berrier, Marie-Paule Jouannetaud, Fabien Zunino. Vinca Alkaloids in Superacidic Media: A Method for Creating a New Family of Antitumor Derivatives J. Am. Chem. Soc., 1997^
  18. Anna Kruczynski, Jean-Marc Barret, Chantal Etiévant, Francis Colpaert, Jacques Fahy, Bridget T. Hill. Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid Biochem. Pharmacol., 1998^
  19. Vinflunine, solution concentration for I.V. infusion, 50 mg in 2 mL and 250 mg in 10 mL (as ditartrate), Javlor® – November 2011 Pharmaceutical Benefits Scheme, March 16, 2012, retrieved June 22, 2017^
  20. Patent combining ciclopirox olamine and piroctone olamine^
  21. Efficacy of Combined Ciclopirox Olamine and Piroctone Olamine in the Treatment of Seborrheic Dermatitis^
  22. pbouchayer. History Fondation Pierre Fabre, retrieved 2021-09-19^
  23. pbouchayer. DNA Fondation Pierre Fabre, retrieved 2021-09-19^