1927–1933
Built by Cadillac to its high standards but at a dedicated factory at Wyoming Road Assembly, the LaSalle soon emerged as a trend-setting automobile. Earl was then placed in charge of overseeing the design of all of General Motors' vehicles. Earl's design even included a nod to the inspirational Hispano-Suiza H6, with the marque's circled trademark "LaS" cast into the horizontal tie bar between the front lights.
There were two wheelbase choices where Fisher offered eight selections while Fleetwood Metal Body offered four coachwork choices on the shorter 128 in while only Fisher offered an additional three coachwork choices on the longer 134 in. For 1927, the most exclusive Fleetwood body was the Transformable Town Cabriolet at US$4,700 ($0 in dollars ). The LaSalles of this era were equipped with Cadillac's "Ninety Degree V-8", making the car fast, while its smaller size made it sportier and more agile.
On June 20, 1927, a LaSalle driven by Willard Rader, along with Gus Bell, on the track at the Milford Proving Grounds, achieved 952 mi, averaging 95.2 mi/h, with only seven minutes given over to refueling and tire changes. In comparison, the average speed at that year's Indianapolis 500 was 97.5 mi/h. The test at Milford would have continued, but a problem in the oil system drew the test to an early close.
The Series 303 [2] continued for 1928, and as LaSalle sales began to progress, engineering advancements, appearance changes and optional equipment choices continued. Shock absorbers were now sourced from Lovejoy hydraulic units and the clutch was now upgraded to twin discs. The list of available coachwork choices from Fisher expanded to eleven selections on the 125" wheelbase and six choices on the 134", while Fleetwood now provided two choices on the 125" and only one choice on the 134", that being the Transformable Town Cabriolet at US$4,900 ($0 in dollars ).
The first engine upgrade to the LaSalle was introduced in 1929 with the Series 328, which had slight differences to the Cadillac V8 which was also upgraded. The Victoria and business coupe were replaced with the Landau Cabriolet from Fisher while Fleetwood choices were all cabriolet coupes or sedans. Both wheelbase choices were both available for Fisher and Fleetwood coachwork selections. September 1929 is when Cadillac introduced its all-new 1930 Series 353, one month before the Cadillac V-12 and the Wall Street Crash of 1929
The ultra-luxury Cadillac V-16 made its grand introduction January 1930, and the LaSalle received another engine upgrade introduced in the LaSalle Series 340. Fisher body selections were reduced to seven closed while Fleetwood choices expanded to six. The only wheelbase used was 134" and a radio was first introduced as an optional item for US$175 ($0 in dollars ) and all LaSalle's were prewired with an antenna imbedded in the roof. Wheels were available in hickory artillery style, wire wheels or solid pressed steel discs. The engine displacement of the 1930 LaSalle and the 1928–1929 Cadillac Series 341 were essentially identical so the LaSalle was labeled as Series 340 while the 1930 Cadillac V8 was upgraded to Series 353. In an attempt to further add exclusivity, Fleetwood convertible coachwork selections were further distinguished by the descriptions "Fleetcliffe", "Fleetlands", "Fleetway" and "Fleetwind" which didn't continue for 1931. The next vehicle choice offered by GM was the all-new Buick Series 50 coupe or sedan with a straight-eight engine with a similar appearance and a Fisher Body for US$1,540 ($0 in dollars ) while a LaSalle Series 340 sedan was listed at US$2,565 ($0 in dollars ).
The 1931 LaSalle's engine was again upgraded and the Series 345-A appeared with the same appearance, engineering and optional equipment changes. Fisher and Fleetwood coachwork choices were again changed based on popularity, and additional optional equipment was added retaining the 134" wheelbase used the previous year. The Cadillac Heron or Goddess hood ornament made the options list for US$20 ($0 in dollars ) while the latest fashion accessory called a radiator rock screen could be installed for US$33 ($0 in dollars ).
From the mid-1910s, a V8 engine was regarded as a luxury expectation, while other manufacturers remained with straight-8 engines, but in 1932 the Ford V8 was introduced with a standard equipment V8 displacing 221 cuin. Body style selections and a wide arrange of Duco automotive lacquer paint color selections, introduced by DuPont, were beginning to become commonplace. The 1932 LaSalle Series 345-B and 1933 Series 345-C followed the same pattern of appearance, engineering upgrades and ever-growing options list.