Plot
In 2020, animals mutated into anthropomorphic creatures called "mutes". Mutes rose up against the human race, forcing the majority of it to live in underground cities called burrows. In the 23rd century, Los Angeles has been reduced to a post-apocalyptic wasteland collectively known as "Las Vistas".
In the first season, Kipo Oak, a thirteen-year-old girl, is separated from her father Lio after their burrow is attacked by a "mega monkey", a colossal, mutated spider monkey. Traversing Las Vistas, she befriends Wolf, a cold and hardened girl who has been surviving on her own after her adoptive wolf family turned on her, the upbeat Benson and his insect companion Dave, and the mute pig Mandu.[5] Together, they set out to find the burrow Kipo's community fled to after their first one was destroyed. During their adventures, Kipo discovers that she has the DNA of a mega jaguar, and can transform her body. As the five journey along they make many mute allies and enemies, including the tyrant Scarlemagne, a mandrill mute who intends to subjugate humanity with his mind-controlling pheromones and force the other mutes into an utopian empire which he will rule with a human army.
In the second season, Kipo learns she was experimented on with mute DNA by her parents before her birth, turning her into a half-human, half-jaguar hybrid, and that her mother Song, previously thought to be deceased, is actually the mega monkey who destroyed her burrow, mutated as a side effect from her pregnancy and mind-controlled with Scarlemagne's pheromones by Dr. Emilia, her parents' former employer who now leads a resistance group against mutes. She also discovers that Scarlemagne was originally an ordinary mandrill named Hugo whom Kipo's parents turned sentient and secretly raised as their son, but grew to hate them after they were forced to abandon him. Kipo frees Song from her mind control and defeats Scarlemagne, while Emilia plots to revert mutes back into normal animals.
In the third season, Kipo creates the "Human Mute Ultimate Friendship Alliance" (HMUFA) to fight Emilia, but struggles to make humans and mutes work together. Emilia creates an anti-mute cure with Kipo's DNA, and it is with this cure that Kipo turns her mother human again. Ultimately, Kipo succeeds in making peace between mutes and humans, reforming Scarlemagne in the process. With her plans foiled and unwilling to accept change, Emilia turns herself into a mega mute to kill Kipo and her friends, but she is defeated with Scarlemagne's help, who sacrifices himself to save Kipo. Five years later, Kipo happily lives on the surface where humans and mutes finally co-exist in harmony.
