As a MyNetworkTV affiliate
On January 24, 2006, the Warner Bros. unit of Time Warner and CBS Corporation announced that the two companies would shut down The WB and UPN and combine the networks' respective programming to create The CW, a new "fifth" network that would combine programming from both The WB and UPN.[12][13] The market's WB station, KWBP (channel 32, now KRCW-TV), was named as The CW's Portland affiliate through a 16-station group agreement with KWBP's owner, the Tribune Company. One month later on February 22, 2006, News Corporation announced the launch of a new "sixth" network called MyNetworkTV, which would be operated by Fox Television Stations and its syndication division Twentieth Television.[14][15] On March 9, 2006, it was announced that KPDX would become a charter affiliate of the new network.
KPDX dropped the UPN branding on April 1, 2006, rebranding from "UPN 49" to "PDX 49", and adopted a new logo in the process. This change of branding had been planned before UPN's shutdown was announced, but the timing of the change was convenient for the upcoming affiliation switch. KPDX's move mirrored one implemented at future MyNetworkTV station WDCA in Washington, D.C. (which branded as "DCA 20"), in using the last three letters of its callsign as its station branding. KPDX retained this branding following MyNetworkTV's launch, and is one of the few MyNetworkTV affiliates to not adopt the network's "blue TV" logo and/or branding style at any point.
On September 8, 2008, KPDX moved MyNetworkTV programming from 8–10 p.m. to 9–11 p.m., making it one of five MyNetworkTV stations at the time that did not air the network's programming in its normal 8–10 p.m. timeslot (KEVU-LP in Eugene, KRON-TV in San Francisco, KQCA in Sacramento, and KMYQ (now KZJO) in Seattle were the others). Concurrent with the schedule change and in anticipation of the station's 25th anniversary, KPDX's on-air brand was modified from "PDX 49" to "PDX TV".
On September 8, 2015, Media General announced that it would acquire Meredith for $2.4 billion, with the combined group to be renamed Meredith Media General once the sale was finalized by June 2016. Because Media General already owned CBS affiliate KOIN (channel 6) and Meredith owns KPTV and KPDX, the companies would have been be required to sell either KPTV or KOIN to comply with FCC ownership rules that forbid common ownership of two of the four highest-rated television stations in a given market in total day viewership, as well as recent changes to FCC ownership rules that restrict sharing agreements; KPDX was the only one of the three stations affected by the merger that could legally be acquired by Meredith Media General, as its total day viewership ranks below the top-four ratings threshold.[16][17] However, on January 27, 2016, Nexstar Broadcasting Group announced that it had reached an agreement to acquire Media General, resulting in the termination of Meredith's acquisition by Media General.
On February 12, 2018, KPDX branding was changed from PDX-TV to "Fox 12 Plus", as an extension of KPTV's "Fox 12 Oregon" branding.[18]