Irbesartan

Irbesartan, sold under the brand name Aprovel among others, is a medication used to treat hypertension (high blood pressure), heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth. Versions are available as the combination irbesartan/hydrochlorothiazide.[5][6]

Medical uses

Irbesartan is used for the treatment of hypertension. It may also delay progression of diabetic nephropathy and is also indicated for the reduction of renal disease progression in patients with type 2 diabetes,[7] hypertension and microalbuminuria (>30 mg/24 h) or proteinuria (>900 mg/24 h).[8]

Side effects

Common side effects include dizziness, diarrhea, feeling tired, muscle pain, and heartburn. Serious side effects may include kidney problems, low blood pressure, and angioedema. Use in pregnancy may harm the baby and use when breastfeeding is not recommended.[1]

Mechanism of action

Irbesartan is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.[13]

History

Irbesartan was developed by Sanofi Research (part of Sanofi-Aventis). It is jointly marketed by Sanofi-Aventis and Bristol-Myers Squibb under the brand names Aprovel, Karvea, and Avapro.[3][1]

It was patented in 1990, and approved for medical use in 1997.[14] It is available as a generic medication.[15] In 2023, it was the 134th most commonly prescribed medication in the United States, with more than 4million prescriptions.[16][17]

Society and culture