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Ibuprofen/paracetamol

Ibuprofen/paracetamol, sold under the brand name Combogesic among others, is a fixed-dose combination of two medications, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID); and paracetamol (acetaminophen), an analgesic and antipyretic.[5] It is available as a generic medication.[8][9]

Medical uses

Ibuprofen/paracetamol is indicated for the short term management of mild to moderate acute pain.[6]

There is evidence that paracetamol combined with ibuprofen provides pain relief better than either medication used alone.[10][11]

Adverse effects

Society and culture

Brand names

The combination is available as Combiflam,[12][13] Advil Dual Action with Acetaminophen,[14][15][16] Ibupane,[17] Nuromol and Combogesic.[6]

References

  1. Nuromol Dual Action Pain Relief 200mg/500mg tablets - Summary of Product Characteristics (SmPC) (emc), 15 June 2022, retrieved 24 February 2023^
  2. Nuromol Pain Relief 200mg/500mg Film Coated Tablets - Summary of Product Characteristics (SmPC) (emc), 15 June 2022, retrieved 24 February 2023^
  3. Nuromol public assessment report GOV.UK, 16 August 2021, retrieved 24 February 2023^
  4. Nuromol Dual Action Pain Relief 200mg/500mg tablets (ibuprofen/paracetamol): public consultation GOV.UK, 13 May 2021, retrieved 24 February 2023^
  5. Advil Dual Action with Acetaminophen- ibuprofen, acetaminophen tablet, film coated DailyMed, 1 December 2021, retrieved 25 February 2023^
  6. Combogesic- acetaminophen and ibuprofen tablet, film coated DailyMed, 9 March 2023, retrieved 6 July 2024^
  7. Combogesic IV- acetaminophen and ibuprofen injection injection DailyMed, 29 April 2024, retrieved 6 July 2024^
  8. Competitive Generic Therapy Approvals U.S. Food and Drug Administration (FDA), 29 June 2023, retrieved 29 June 2023^
  9. First Generic Drug Approvals 2023 U.S. Food and Drug Administration (FDA), 30 May 2023, retrieved 30 June 2023^
  10. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain Anesthesia and Analgesia, April 2010^
  11. Efficacy of OTC analgesics. International Journal of Clinical Practice. Supplement, January 2013^
  12. Combiflam drugs.com, retrieved 5 February 2015^
  13. Combiflam Sanofi India, 28 February 2023, retrieved 2 March 2023^
  14. Advil Dual Action: FDA-Approved Drugs U.S. Food and Drug Administration (FDA), retrieved 28 February 2020^
  15. Drug Approval Package: Advil Dual Action with Acetaminophen U.S. Food and Drug Administration (FDA), 31 March 2020, retrieved 2 March 2023^
  16. FDA approves GSK's Advil Dual Action with Acetaminophen for over-the-counter use in the United States GSK Consumer Healthcare, 28 February 2020, retrieved 28 February 2020^
  17. Ibupane TGA eBS, retrieved 29 April 2023^