Glecaprevir/pibrentasvir (G/P), sold under the brand names Mavyret and Maviret, is a fixed-dose combination medication used to treat hepatitis C. It contains glecaprevir and pibrentasvir. It works against all six types of hepatitis C. At twelve weeks following treatment between 81% and 100% of people have no evidence of hepatitis C. It is taken once a day by mouth with food.
The most common side effects are headache, diarrhea, and tiredness.[4][5] In those with a history of hepatitis B, reactivation may occur.[5] It is not recommended in people with moderate to severe liver disease.[4] Glecaprevir works by blocking the protein NS3/4A protease, while pibrentasvir works by blocking NS5A.
The combination was approved for medical use in the United States and Europe in 2017.[6]