Ethinylestradiol/drospirenone

Ethinylestradiol/drospirenone (EE/DRSP), sold under the brand name Yasmin among others, is a combination of ethinylestradiol (EE), an estrogen, and drospirenone (DRSP), a progestin, antimineralocorticoid, and antiandrogen, which is used as a birth control pill to prevent pregnancy in women.[4][5][6][7][8] It is also indicated for the treatment of moderate acne, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and dysmenorrhea (painful menstruation) in women.[5] The medication is taken by mouth and contains 30 μg EE and 3 mg DRSP per tablet (brand names Yasmin, others) or 20 μg EE and 3 mg DRSP per tablet (brand names Yaz, Yasminelle, Nikki, others).[6][7] A formulation with levomefolic acid (vitamin B9) has also been marketed (brand names Beyaz, Safyral, others), with similar indications.[9][10] EE/DRSP is marketed widely throughout the world.[11]

In 2023, it was the 154th most commonly prescribed medication in the United States, with more than 3million prescriptions.[12][13]

See also

  • Ethinylestradiol/drospirenone/levomefolic acid
  • Ethinylestradiol/drospirenone/prasterone
  • Estradiol/drospirenone
  • List of combined sex-hormonal preparations § Estrogens and progestogens

References

  1. Drospirenone / estradiol (Angeliq) Use During Pregnancy Drugs.com, 6 September 2018, retrieved 18 March 2020^
  2. healthdirect.gov.au. Yasmin^
  3. healthdirect.gov.au. Yaz^
  4. Ethinylestradiol/Drospirenone AdisInsight, Springer Nature Switzerland AG^
  5. Drospirenone/Ethinylestradiol low-dose - Bayer HealthCare Pharmaceuticals AdisInsight, Springer Nature Switzerland AG^
  6. Yasmin- drospirenone and ethinyl estradiol kit DailyMed, 19 May 2023, retrieved 26 October 2024^
  7. Yaz- drospirenone and ethinyl estradiol kit DailyMed, 19 May 2023, retrieved 26 October 2024^
  8. Ethinylestradiol/drospirenone: a review of its use as an oral contraceptive Treatments in Endocrinology, 2003^
  9. Ethinylestradiol/Drospirenone/Folic acid AdisInsight, Springer Nature Switzerland AG^
  10. Beyaz- drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium kit DailyMed, 19 May 2023, retrieved 26 October 2024^
  11. Drospirenone Uses, Side Effects & Warnings Drugs.com^
  12. Top 300 of 2023 ClinCalc, retrieved 12 August 2025^
  13. Drospirenone; Ethinyl Estradiol Drug Usage Statistics, United States, 2013 - 2023 ClinCalc, retrieved 19 August 2025^