Research collaborations
In 2007, Curevac received the innovation prize of the state of Baden-Württemberg[12] and was also the winner of the nationwide Weconomy competition, which is jointly awarded by the Handelsblatt newspaper and the Wissensfabrik.[13]
In October 2013, CureVac launched a collaboration with Janssen Pharmaceuticals Inc., a Johnson & Johnson company, for the development of novel flu vaccines.[14] Also in 2013, CureVac announced the fourth in a series of partnerships with the Cancer Research Institute and Ludwig Cancer Research to enable clinical testing of novel cancer immunotherapy treatment options.[15]
In March 2014, CureVac won a €2 million prize awarded by the European Commission to stimulate new vaccine technologies.[16] Later, in July 2014, CureVac signed an exclusive license agreement with Sanofi Pasteur to develop and commercialize an mRNA-based prophylactic vaccine.[17] By September 2014, the company licensed the global rights for its Phase I candidate – CV9202 – to Boehringer Ingelheim. Boehringer was to conduct trials using the mRNA vaccine in combination with afatinib in advanced and/or metastatic epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC) as well as inoperable stage III NSCLC.[18]
In March 2015, a CureVac investor, the Bill & Melinda Gates Foundation, agreed to provide separate funding for several projects to develop prophylactic vaccines based on CureVac's proprietary mRNA platform.[19] By September 2015, CureVac entered into a collaboration with the International AIDS Vaccine Initiative (IAVI) to accelerate the development of AIDS vaccines, utilizing immunogens developed by IAVI and partners, delivered via CureVac's mRNA technology.[20] That same month, CureVac announced it would open a United States hub in Boston, Massachusetts.[21]
In accordance with its deal with Eli Lilly and Company, the company began construction on a production facility in 2016.[22]
In February 2019, the Coalition for Epidemic Preparedness Innovations (CEPI) awarded CureVac a $34 million grant to develop its proprietary "RNA printer" prototype.[23] The technology is expected to allow the company to rapidly produce mRNA vaccine candidates at scale from multiple locations globally to bypass the logistical hurdles that often delay the production of vaccines in response to infectious disease emergencies. It is also expected to enable the production of personalized medicines.[23] The initial uses would be for their candidate vaccines for Lassa fever, yellow fever, and rabies.[23]
In July 2020, Tesla, Inc CEO Elon Musk announced via a Tweet that Tesla and CureVac had reached an agreement to produce portable "RNA microfactories" based on this technology to manufacture CureVac's COVID-19 vaccine candidate.[23] CureVac had stated that the bioprinters would be able to produce “more than a hundred thousand doses” within approximately two weeks.[23] At approximately the same time, Tesla and CureVac filed a joint patent on the technology.[24] In August, Musk reviewed the project with Curevac while in Germany.[24]
Investment
By 2017, CureVac had received investments of approximately €305 million in the form of equity and was valued at €1.40 billion.[25] In June 2020, the federal government announced that the state-owned development bank KfW would immediately invest €300 million in CureVac, which will mean that it will hold a 23% stake in CureVac.[26]
On 14 August 2020, CureVac began public trading on the NASDAQ exchange under the ticker symbol, CVAC, raising US$213 million in its initial public offering.[27]
Reports of Trump administration overtures
On 11 March 2020, it was reported that CureVac AG's CEO Daniel Menichella was no longer the company's CEO, having been replaced by the company founder Ingmar Hoerr. Menichella was reported to have met U.S. President Donald Trump on 2 March.[28][29] According to Welt am Sonntag, quoting an anonymous German government source, Trump had attempted to persuade CureVac to relocate to the United States, a proposal vigorously rejected by German officials.[30] On 16 March, CureVac issued a statement on Twitter, stating "To make it clear again on coronavirus: CureVac has not received from the US government or related entities an offer before, during and since the Task Force meeting in the White House on March 2. CureVac rejects all allegations from press."[31]
