Cubist Pharmaceuticals

Cubist Pharmaceuticals, Inc. was an American biopharmaceutical company that targeted pathogens like MRSA.

.[1] The company employed 638 people, mostly in Lexington, Massachusetts.[2] On 8 December 2014, Merck & Co. acquired Cubist for $102 per share in cash ($8.4 billion).[3]

History

Cubist was founded in May 1992 by John K. Clarke, Paul R. Schimmel, Ph.D. and Barry M. Bloom, Ph.D, all of whom were also directors.[4] Cubist appeared on Fortune 2010’s List of fastest growing companies, and was named to the 2010 Deloitte Technology Fast 500.[5]

In 2011, the company acquired Adolor, maker of a drug for treatment of constipation.

In July 2013, Cubist Pharmaceuticals agreed to purchase Trius Therapeutics and Optimer Pharmaceuticals for around $1.6 billion.[6]

In 2014, succeeding Michael Bonney as President, Robert J. Perez, was announced to take leadership on January 1, 2015.[7]

In January 2015, Cubist Pharmaceuticals became a wholly owned subsidiary of Merck & Co.[8][9]

Products

The company developed Cubicin (daptomycin) for injection, the first antibiotic in a class of anti-infectives called lipopeptides. In 2011, Cubist settled a patent litigation with Teva Pharmaceutical Industries regarding Cubicin.[10] In April 2011 it reached a deal with Optimer Pharmaceuticals in which its class of bacterium-fighting drugs will be co marketed with Optimer's Fidaxomicin/Dificid (for $15 million per year).[11]

In 2011, its product pipeline focused on gram-negative bacterial infections,[12] Clostridioides difficile infection,[13] and respiratory syncytial virus.[14]

Tedizolid was approved by the US Food and Drug Administration on June 20, 2014.[15][16]

References

  1. Emily Mullin. Cubist exec: Challenges mount in antibiotics discovery Fiercebiotechresearch.com, 26 Aug 2014, retrieved 23 Nov 2014^
  2. Cubist Pharmaceuticals Inc. homesite 2009 Annual Report, retrieved 20 May 2011^
  3. Vidya Nathan. Merck to take on superbugs with Cubist Pharma buy Reuters, 9 December 2014^
  4. SEC Form S3 Cubist Pharmaceuticals, Inc. March 8, 2000^
  5. 100 FASTEST-GROWING COMPANIES CNN, 2010, retrieved 28 May 2011^
  6. Vrinda Manocha and Zeba Siddiqui. Cubist to pay up to $1.6 billion for two antibiotics makers Reuters, 30 July 2013^
  7. Robert Weisman. New Cubist Pharmaceuticals chief executive will be Robert J. Perez www.BostonGlobe.com, 20 Oct 2014, retrieved 23 Nov 2014^
  8. David Gelles. Merck in $8.4 Billion Deal for Cubist, Big Maker of Antibiotics The New York Times, 2014-12-08, retrieved 2026-02-24^
  9. Damian Garde. Merck dumps 120 Cubist researchers after its $9.5B merger www.fiercebiotech.com, 2015-03-05, retrieved 2026-03-10^
  10. Cubist Settles Teva Patent Litigation on Antibiotic Cubicin Bloomberg, 2011-04-05, retrieved 28 May 2011^
  11. Optimer to Market Dificid Drug With Cubist Pharmaceuticals Bloomberg, 2011-04-06^
  12. Julie M. Donnelly. Cubist advances antibiotic for Gram-negative bacteria www.bizjournals.com, 13 December 2011, retrieved 2017-10-31^
  13. Rodney H. Brown. Cubist – Optimer diarrhea drug could net $47M www.bizjournals.com, 6 April 2011, retrieved 2017-10-31^
  14. Alnylam Loses Cubist as RSV Partner, Stays Focused on ATTR Programs GenomeWeb, retrieved 2017-10-31^
  15. Sivextro by Cubist Pharmaceuticals Pharmacy Times, 17 September 2014, retrieved 2017-10-31^
  16. Cubist Announces FDA Acceptance of Tedizolid New Drug Application with Priority Review www.fiercebiotech.com, 30 December 2013, retrieved 2017-10-31^
  17. Cubist Profit Down 53% Advantage Business Media, 19 Jan 2012, retrieved 22 Jan 2012^