2015–2020
In March 2015, the company announced that it would license its Phase II candidate drug AMG 714 to Celimmune, which will develop the anti-IL-15 monoclonal antibody for treatment against diet nonresponsive celiac disease and refractory celiac disease.[38] In August 2015, Repatha (evolocumab) was approved by the FDA.[39]
In September 2016, the company announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of multiple myeloma.[40] Also in September, the FDA approved Amjevita (adalimumab-atto).[41] The FDA approved Parsabiv in February 2017[42] and Mvasi (bevacizumab-awwb) in September.[43]
In July 2018, Amgen began constructing a biomanufacturing plant at its campus in West Greenwich, Rhode Island.[44][45]
In January 2019, Evenity (romosozumab) received approval in Japan,[46][47] followed by FDA approval in April.[48] In June, Kanjinti (trastuzumab-anns) was approved by the FDA.[49]
In December 2019, the FDA approved Avsola (infliximab-axxq).[50]
In September 2019, FDA granted fast track designation to sotorasib for the treatment of metastatic non-small-cell lung carcinoma (NSCLC) with the KRAS G12C mutation.[51]
In April 2020, Amgen established Amgen K.K. as the company's wholly owned affiliate in Japan.[52][53] The company announced in July that the United States Court of Appeals for the Federal Circuit had upheld the validity of two Amgen patents that described and claimed Enbrel and methods for making it. The appellate court affirmed an August 2019 decision by the United States District Court for the District of New Jersey and rejected Sandoz's attempt to invalidate the patents on Enbrel.[54]
In August 2020, Amgen, Takeda Pharmaceutical Company, and AbbVie, as part of a COVID-19 research and development (R&D) alliance, announced the first patients enrolled in the I-SPY COVID clinical trial. The trial evaluated the efficacy of Otezla and two other medicines in severely ill, hospitalized COVID-19 patients who required high-flow oxygen.[55]
In September 2020, Amgen and Eli Lilly and Company announced a global manufacturing collaboration for COVID-19 antibody therapies.[56]
In October 2020, Amgen announced positive topline Phase 2 results from the CodeBreaK 100 clinical study, evaluating sotorasib in 126 patients with KRAS G12C-mutant advanced NSCLC who had failed three or fewer prior lines of anti-cancer therapies (including immunotherapy and/or chemotherapy).[57] Amgen, the Global Coalition for Adaptive Research, and Eisai Co., Ltd. also announced enrollment of the first patient in a study testing multiple interventions for the treatment of patients hospitalized with COVID-19.[58]
In November 2020, Amgen, Takeda, and UCB, as part of the COVID R&D alliance, announced the first patient enrolled in another trial evaluating Otezla and two other drugs as treatments for COVID-19.[59] Amgen also announced that it would terminate its collaboration with Cytokinetics and transition the development and commercialization rights for omecamtiv mecarbil and AMG 594.[60] Amgen and AstraZeneca announced positive topline results from a Phase 3 trial in which the investigational medicine tezepelumab demonstrated a statistically significant reduction in exacerbations in patients with severe asthma.[61]
In December 2020, the FDA granted breakthrough therapy designation to sotorasib for advanced or metastatic non-small cell lung cancer patients with KRAS G12C mutation.[62] Also in December 2020, the FDA approved Riabni (rituximab-arrx), a biosimilar to Rituxan.[63][64]
In April 2021, the company acquired Five Prime Therapeutics and its lead candidate, bemarituzumab, for $1.9 billion.[65][66][67][68]
In the March 2021, Amgen acquired Rodeo Therapeutics for $720 million.[69][70]
In May 2021, sotorasib received accelerated approval from FDA for treatment of adult patients with NSCLC whose tumors have a KRAS G12C mutation and who have received at least one prior systemic therapy; this was the first approved targeted therapy for tumors with any KRAS mutation.[71] Similar approvals for sotorasib in NSCLC followed in January 2022 in Europe[72] and Japan.[73] The FDA approved Amgen's Lumakras in May for treatment of patients with KRAS-G12C-mutated non-small cell lung cancer.[74]
In June 2021, Amgen and Kyowa Kirin announced joint plans to develop and commercialize a treatment for atopic dermatitis.[75] In October, Amgen and Neumora Therapeutics announced a research and development collaboration focused on novel precision therapies for certain brain diseases.[76][77] Amgen began construction on a new biomanufacturing plant in New Albany, Ohio, in November.[78] In December, the FDA approved Amgen and AstraZeneca's Tezspire (tezepelumab) for severe asthma.[79] The FDA also approved Amgen's Otezla for adults with plaque psoriasis of any severity level.[80]
Amgen announced a research collaboration in January 2022 with Generate Biomedicines across multiple modalities and several therapeutic areas for up to $1.9 billion.[81][82] The company also launched a multi-target collaboration with Arrakis Therapeutics to identify novel targeted RNA degrader therapeutics.[83][84] The next month, Amgen entered a multi-year collaboration with Plexium to discover novel targeted protein degradation therapies.[85][86] Also in February, Amgen issued its first green bond to fund various environmentally friendly initiatives across the company.[87][88]
In September 2022, data from a late-stage study showed the company's cancer pill Lumakras (sotorasib) beating out chemotherapy. This was the first approved drug in the set of treatments that target KRAS, among the most common generic mutations found in cancers. The drug was approved in 2021 with a list price of $17,900 per month.[91]
In October 2022, the company acquired ChemoCentryx, the maker of Tavneos—a drug treatment for rare diseases called anti-neutrophil cytoplasmic autoantibody-associated vasculitis, for $3.7 billion in an all-cash deal.[92][93][94]
In October 2023, Amgen acquired Horizon Therapeutics, specializing in drugs for rare diseases, for $27.8 billion.[95][96]
In November 2023, Amgen announced plans to use artificial intelligence in partnership with Amazon Web Services to help discover and create medicines and use the Amazon SageMaker machine learning service to help with the manufacturing process.[97]
In March 2025, data for the drug Tezspire (tezepelumab), showed the best results for treating chronic rhinosinusitis with nasal polyps.[98]
Also in March 2025, Amgen announced the start of two late-stage trials for MariTide, an anti-obesity medication candidate.[99][100] In June 2025, the company noted that it had to reduce the dosage of the drug to avoid side effects such as vomiting.[101] However, patients that continued to take the drug lost approximately 20% of their body weight.[102]
In April 2025, the company announced a $900 million expansion of its facility in New Albany, Ohio.[103] In September 2025, it announced plans to build a $600 million research center in Thousand Oaks, California.[104]
