Abacavir/lamivudine/zidovudine, sold under the brand name Trizivir, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS.[2] It contains three reverse transcriptase inhibitors patented by GlaxoSmithKline and marketed by a joint venture with Pfizer, ViiV Healthcare:[3]
It is indicated in the treatment of AIDS/HIV-1.[4] For this purpose, the combination is very useful in pregnant women to decrease the risk of mother-to-child transmission.[5]
The most common effects include headache and nausea (feeling sick).
Abacavir/lamivudine/zidovudine was approved for use in the United States and the European Union in 2000.[6][7] In December 2013, Lupin Limited launched a generic version of abacavir/lamivudine/zidovudine.[8][9][10]
- abacavir sulfate (ABC)
- lamivudine (3TC)
- zidovudine (AZT or ZDV)
Side effects
The most common side effects of abacavir/lamivudine/zidovudine include nausea, vomiting, diarrhea, fatigue, paresthesia and headache. As with many medications targeting reverse transcriptase, body fat redistribution syndrome may occur, causing body fat to center on the upper back and neck, breast, and torso, and potentially decreasing around the legs, arms, and face.[11] IRIS may occur which is when the immune system initially improves, but then deteriorates as a previously ignored infection becomes active. Other serious side effects include:[12]
- Increased risk of heart attack
- Lactic acidosis
- Severe hepatomegaly
- Lipoatrophy
- Neutropenia
- Anemia
See also
- Abacavir/lamivudine
- Abacavir/dolutegravir/lamivudine
External links
References
- Abacavir / lamivudine / zidovudine (Trizivir) Use During Pregnancy Drugs.com, 8 May 2018, retrieved 7 April 2020^
- A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection The Journal of Infectious Diseases, May 2002^
- GlaxoSmithKline-Pfizer launch HIV joint venture InPharm.com^